Performance decay

Production and maintenance planning optimisation in biopharmaceutical processes under performance decay using a continuous-time formulation: A multi-objective approach

M. Vieira, T. Pinto-Varela, A.P. Barbosa-Póvoa

Computers and Chemical Engineering (Published)

Mar, 2017

Keywords: Biopharmaceutical plants Production and maintenance planning Performance decay Multi-objective optimisation

This paper presents a mixed integer linear programing (MILP) model, based on a continuous-time Resource Task Network (RTN) formulation, for the optimal planning/scheduling of biopharmaceutical processes. The model proposes the integration of the production planning with the required…

Optimisation of Maintenance Planning into the Production of Biopharmaceuticals with Performance Decay using a Continuous-time Formulation

M. Vieira, S. Liu, T. Pinto-Varela, A.P. Barbosa-Póvoa, L.G. Papageorgiou

Computer Aided Chemical Engineering (Published)

Jun, 2016

Keywords: optimisation maintenance planning performance decay