Biopharmaceutical plants

Production and maintenance planning optimisation in biopharmaceutical processes under performance decay using a continuous-time formulation: A multi-objective approach

M. Vieira, T. Pinto-Varela, A.P. Barbosa-Póvoa

Computers and Chemical Engineering (Published)

Mar, 2017

Keywords: Biopharmaceutical plants Production and maintenance planning Performance decay Multi-objective optimisation

This paper presents a mixed integer linear programing (MILP) model, based on a continuous-time Resource Task Network (RTN) formulation, for the optimal planning/scheduling of biopharmaceutical processes. The model proposes the integration of the production planning with the required…

Optimal planning and campaign scheduling of biopharmaceutical processes using a continuous-time formulation

M. Vieira, T. Pinto-Varela, S. Moniz, A.P. Barbosa-Póvoa, L.G. Papageorgiou

Computers & Chemical Engineering (Published)

Aug, 2016

Keywords: Biopharmaceutical plants Planning and campaign scheduling Optimisation Mixed integer linear programming

This work addresses the optimal planning and campaign scheduling of biopharmaceutical manufacturing processes, considering multiple operational characteristics, such as the campaign schedule of batch and/or continuous process steps, multiple intermediate deliveries, sequence…