maintenance planning

Optimisation of Maintenance Planning into the Production of Biopharmaceuticals with Performance Decay using a Continuous-time Formulation

M. Vieira, S. Liu, T. Pinto-Varela, A.P. Barbosa-PĆ³voa, L.G. Papageorgiou

Computer Aided Chemical Engineering (Published)
Jun, 2016

This paper presents a mixed integer linear programing (MILP) model, based on a continuous-time Resource Task Network (RTN) formulation, for the optimal planning/scheduling of biopharmaceutical processes. The model proposes the integration of the production planning with the required…

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