pharmaceutical industry

Optimization and Monte Carlo Simulation for Product Launch Planning under Uncertainty

C.M. Marques, S. Moniz, J.P. de Sousa, A.P. Barbosa-Póvoa

Computer Aided Chemical Engineering (Published)

Jan, 2016

Keywords: Process Design Capacity Planning Pharmaceutical Industry MILP Monte Carlo Simulation

This paper presents an innovative approach to solve the product-launch planning problem in the pharmaceutical industry, with uncertainty on the product demand and on clinical trials. A mixed integer linear programming (MILP) model, incorporating Monte Carlo simulation (MCS), was developed for…

On the complexity of production planning and scheduling in the pharmaceutical industry: the Delivery Trade-offs Matrix

S. Moniz, A.P. Barbosa-Póvoa, J.P. de Sousa

Computer Aided Chemical Engineering (Published)

Jun, 2015

Keywords: Planning scheduling pharmaceutical industry

The manufacturing of pharmaceutical products is preceded by complex development phases where process design, planning, and scheduling problems must be considered as deeply linked, fact that has not yet been adequately handled by the existing literature. In this perspective, this work discusses the…