Optimal planning and campaign scheduling of biopharmaceutical processes using a continuous-time formulation

M. Vieira, T. Pinto-Varela, S. Moniz, A.P. Barbosa-PĆ³voa, L.G. Papageorgiou
ABSTRACT:

This work addresses the optimal planning and campaign scheduling of biopharmaceutical manufacturing processes, considering multiple operational characteristics, such as the campaign schedule of batch and/or continuous process steps, multiple intermediate deliveries, sequence dependent changeovers operations, product storage restricted to shelf-life limitations, and the track-control of the production/campaign lots due to regulatory policies. A new mixed integer linear programing (MILP) model, based on a Resource Task Network (RTN) continuous time single-grid formulation, is developed to comprise the integration of all these features. The performance of the model features is discussed with the resolution of a set of industrial problems with different data sets and process layouts, demonstrating the wide application of the proposed formulation. It is also performed a comparison with a related literature model, showing the advantages of the continuous-time approach and the generality of our model for the optimal production management of biopharmaceutical processes.

Publisher
Computers & Chemical Engineering (Published)
Date
Aug, 2016
Keywords
Biopharmaceutical plants | Planning and campaign scheduling | Optimisation | Mixed integer linear programming

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