In the present work a design and planning model with uncertainty in products’ demand is applied to two supply chains (SCs): a traditional forward network and a closed-loop supply chain (CLSC). The objective is to maximize the ENPV and evaluate their resilience towards different types of disruption. Four disruptions that affect different SC echelons are implemented, with uncertainty in their occurrence being also considered simultaneously with products’ demand uncertainty. The networks’ resilience is measured using seven indicators. A case study is solved.