Supply chains have become one of the most important strategic themes in the aerospace industry in recent years as globalization and deep technological changes have altered the industry at many levels, creating new dynamics and strategies. In this setting, sustainability at the supply chain level is an emerging research topic, whose contributions aim to support businesses into the future. To do so the development of new products and the response to new industry requirements, while incorporating new materials appears as a path to follow, which require more resilient and agile supply chains, while guaranteeing their sustainability. Such supply chains will be better prepared for the future complex challenges and risks faced by the aerospace companies. Such challenges are addressed in this work, where an integrated framework is proposed to contribute to the resilience and sustainability of aerospace supply chains. Using different analysis methods, the framework addresses four important challenges in the context of aerospace supply chain sustainability: evolution and new trends, performance assessment, supplier selection, and supply chain design and planning.